SourceDepartment of Orthopaedic Surgery, Medical College of Wisconsin, PO Box 26099, West Wisconsin Avenue, Milwaukee, Wisconsin, 53226.
What are vascular endothelial cells?
Vascular endothelial growth factor (VEGF) is a signal protein produced by cells that stimulates vasculogenesis and angiogenesis. It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate. Serum concentration of VEGF is high in bronchial asthma and low in diabetes mellitus. VEGF's normal function is to create new blood vessels during embryonic development, new blood vessels after injury, muscle following exercise, and new vessels (collateral circulation) to bypass blocked vessels.
When VEGF is overexpressed, it can contribute to disease. Solid cancers cannot grow beyond a limited size without an adequate blood supply; cancers that can express VEGF are able to grow and metastasize. Overexpression of VEGF can cause vascular disease in the retina of the eye and other parts of the body. Drugs such as bevacizumab can inhibit VEGF and control or slow those diseases.
Why is this study interesting?
I had a conversation recently with a biochemist who suggested that cobalt not chromium might be the key component for studying cancer related issues surrounding the hip. Thought this was quite an interesting study. In my situation, I have stage 4 renal cell carcinoma. A major component of that disease state is VEGF. Kidney cancer is a very vascular disease.