Saturday, October 27, 2012

Zimmer Holdings Management Discusses Q3 2012 Results - Earnings Call Transcript



"Hip sales in the third quarter increased 1.6%, reflecting positive volume and mix of 4.4%, and negative price of 2.8%. In the quarter, our Americas and Europe, Middle East and Africa operating segments delivered an improved performance, while in Asia-Pacific, sales declined slightly compared with prior year due primarily to the previously discussed pricing pressure in Japan. Across our hip portfolio, we continue to drive benefit from our proprietary technology platforms, including Trabecular Metal Technology, which offers a differentiated advantage in the revision market, as well as its applications and primary acetabular cups and stems.

In the quarter, we also continued the introduction of our VIVACIT-E Highly Crosslinked Polyethylene in the United States, and will soon make this advanced material available to certain European markets."

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I guess we are still using metal technology.

Trabecular metal technology:

Trabecular Metal Technology is a
three-dimensional material, not an implant
surface or coating. Its structure
is similar to cancellous bone.


Trabecular Metal Material’s consistent,
open and interconnected network of pores
is designed for bone on-growth
and in-growth, or osseoincorporation


In a study of Trabecular Metal Implants
placed in canine mandibular models,
evidence of in-growth by maturing bone
has been documented as early as
two weeks after implantation.33,34
Further research is required to
determine the rate of bone in-growth
and its effects on secondary stability
in human dental applications. 
  

The Best Thing Next To Bone™
The cellular structure of Trabecular Metal* resembles bone and approximates its physical and mechanical properties more closely than other prosthetic materials. The unique, highly porous, trabecular configuration is conducive to bone formation, enabling rapid and extensive tissue infiltration and strong attachment.1,2,

Physical Properties

Trabecular Metal consists of interconnecting pores resulting in a structural biomaterial that is 80% porous, allowing approximately 2-3 times greater bone ingrowth compared to conventional porous coatings and double the interface shear strength.1,+
Trabecular Metal Technology
Trabecular Metal implants are fabricated using elemental tantalum metal and vapor deposition techniques that create a metallic strut configuration similar to trabecular bone. The crystalline microtexture of aTrabecular Metal strut is conductive to direct bone apposition.2
The crystalline microtexture of aTrabecular Metal strut
Elemental tantalum unites strength and corrosion resistance with excellent biocompatibility. These characteristics help explain tantalum's surgical use for more than 50 years in applications such as cranioplasty plates and pacemaker leads.3

Mechanical Properties

Trabecular Metal possesses a high strength-to-weight ratio, with mechanical properties capable of withstanding physiologic loading. The compressive strength and elastic modulus of Trabecular Metal are more similar to bone than are other prosthetic load-bearing materials.2,4 The material's low stiffness facilitates physiologic load transfer and helps minimize stress shielding.
Mechanical Properties
The Trabecular Metal struts generate a friction coefficient that is 76% greater than a sintered bead coating, providing increased initial stability.5
Trabecular Metal struts generate a friction coefficient

Exceptional Bone Ingrowth

The bone-like physical and mechanical properties of Trabecular Metal contribute to extensive bone infiltration. A transcortical implant animal study demonstrated that new bone rapidly infiltrated the Trabecular Metal.1,2 Only 8 weeks after surgery, bone had grown into and filled the majority of available pore space. Consequently, fixation strength developed more rapidly. At 4 weeks, the bone interface shear strength of Trabecular Metal material was double that of sintered beads.1,2
Exceptional Bone Ingrowth

Histologic Micrographs

Filling of prepared cortical holes with new bone is comparable with Trabecular Metal implants (top) and without (bottom). 2 Bone filled the majority of the available pore space at 8 weeks.
Trabecular Metal has been shown to permit physiologic bone healing. In 24 week animal studies of Trabecular Metal acetabular cups, the density of ingrown bone was comparable to the density of peri-implant trabecular bone.6

Soft Tissue Attachment

The pore size and high volume porosity of Trabecular Metal supports vascularization and rapid, secure soft tissue ingrowth. In the canine model, soft tissue adherence and vascularization occurred quickly with extensive tissue ingrowth 4 to 8 weeks after surgery.
Soft Tissue Attachment
Soft tissue attachment strength was five times greater than with sintered bead coatings at 4 and 8 weeks.7,8

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I wonder what you would do if you needed a revision with this kind of approach?  it would seem that you might have remove a lot of bone rather than just the implant becuase the implant and bone become one?

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