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Saturday, September 1, 2012
To all of us glucosamine Chondroitin users: Looks like there is some benefit after all!
Institute for Health Care Science, Suntory Wellness Ltd, Mishima-gun, Osaka, Japan. Noriyuki_Kanzaki@suntory.co.jp
Oralglucosamineandchondroitin sulfate, alone and incombination, have been used worldwide for the treatment ofosteoarthritis(OA), but their efficacy is controversial. This clinical study was aimed at investigating the potential of a dietary supplement containingglucosamineandchondroitin sulfateincombinationwith derivatives of quercetin, a naturally occurring flavonoid, (GCQ supplement) forkneeOA care.
A randomized, double-blind, placebo-controlled study was conducted in 40 Japanese subjects with symptomatickneeOA. Subjects were randomly assigned to GCQ supplement (1200 mgglucosaminehydrochloride, 60 mgchondroitin sulfateand 45 mg quercetin glycosides per day) or placebo and the treatment and follow-up were continued for 16 weeks. The results of symptomatic efficacy assessment based on Japanese Orthopaedic Association criteria showed that scores fortwoof the four symptom/function subscales, as well as the aggregate scores, were significantly improved at week 16 or earlier in the GCQ group compared to the placebo group. Moreover, analyses of cartilage metabolism biomarkers showed a trend of improvement in type II collagen synthesis/degradation balance in the GCQ group during follow-up.
GCQ supplement was thought to be more effective than placebo in decreasing the intensity ofkneeOA-associated clinical symptoms.