Study: THA, TKA, and the risk of AMI
A Danish study published online in Archives of Internal Medicine (July 23) finds that the risk of acute myocardial infarction (AMI) is substantially increased in the first 2 weeks following total hip arthroplasty (THA) and total knee arthroplasty (TKA). The retrospective, nationwide cohort study of 95,227 patients who underwent THA or TKA between Jan. 1, 1998, and Dec. 31, 2007, matched each patient to three controls based on age, sex, and geographic region. During the first 2 weeks postoperative, the risk of AMI was increased 25-fold in THA patients compared with controls, and 31-fold for TKA patients compared to controls. For 2 to 6 weeks after surgery, risk of AMI remained elevated for THA patients, but not for TKA patients. Absolute 6-week risk of AMI was 0.51 percent in THA patients and 0.21 percent in TKA patients.