This website is dedicated to providing public information regarding DePuy Hip recall and other related information to the recall. None of the information on this site is intended to be formal legal or medical advice, nor should any information on this site be construed as advice that should be used in lieu of information from your attorney or physician.
Saturday, September 1, 2012
Measuring Cancer risk 4 years post implant with MOM hips
Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI-20701, Turku, Finland.
To assess the risk of cancer associated with modern primarymetal-on-metalhipreplacements.
Population based study.
Nationwide retrospective comparative register.
10 728 patients who underwentmetal-on-metaltotal hip arthroplastyand 18 235 patients who underwent conventionalmetal-on-polyethylene, ceramic-on-polyethylene, and ceramic-on-ceramictotal hip arthroplasty(the non-metal-on-metalcohort) in the FinnishArthroplastyRegister 2001-10. Data on cancer cases up to 2010 for these cohorts were extracted from the Finnish Cancer Registry.
MAIN OUTCOME MEASURES:
The relative risk of cancer was expressed as the ratio of observed to expected number of cases from the Finnish population-that is, the standardised incidence ratio. The relative risk of cancer in themetal-on-metalcohort compared with the non-metal-on-metalcohort was estimated with analyses of these ratios and Poisson regression.
The overall risk of cancer in patients withmetal-on-metalhipimplants was similar to that in the Finnish population (378 observed v 400 expected, standardised incidence ratio 0.95, 95% confidence interval 0.85 to 1.04). The overall risk of cancer in patients withmetal-on-metalhipimplants was also no higher than in patients who had received non-metal-on-metalhipimplants (relative risk 0.92, 0.81 to 1.05).
Metal-on-metalhipreplacements are not associated with an increased overall risk of cancer during a mean follow-up of four years.
I don't think you are going to find cancer 4 years post artheroplasty. I think we have done enough short term studies on this now. We have to start looking at patents 10 years post artheroplastsy.