Saturday, September 1, 2012

Measuring Cancer risk 4 years post implant with MOM hips

 2012 Jul 25;345:e4646. doi: 10.1136/bmj.e4646.

Risk of cancer with metal-on-metal hip replacements: population based study.


Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI-20701, Turku, Finland.



To assess the risk of cancer associated with modern primary metal-on-metal hip replacements.


Population based study.


Nationwide retrospective comparative register.


10 728 patients who underwent metal-on-metal total hip arthroplasty and 18 235 patients who underwent conventional metal-on-polyethylene, ceramic-on-polyethylene, and ceramic-on-ceramic total hip arthroplasty (the non-metal-on-metal cohort) in the Finnish ArthroplastyRegister 2001-10. Data on cancer cases up to 2010 for these cohorts were extracted from the Finnish Cancer Registry.


The relative risk of cancer was expressed as the ratio of observed to expected number of cases from the Finnish population-that is, the standardised incidence ratio. The relative risk of cancer in the metal-on-metal cohort compared with the non-metal-on-metalcohort was estimated with analyses of these ratios and Poisson regression.


The overall risk of cancer in patients with metal-on-metal hip implants was similar to that in the Finnish population (378 observed v 400 expected, standardised incidence ratio 0.95, 95% confidence interval 0.85 to 1.04). The overall risk of cancer in patients with metal-on-metal hipimplants was also no higher than in patients who had received non-metal-on-metal hip implants (relative risk 0.92, 0.81 to 1.05).


Metal-on-metal hip replacements are not associated with an increased overall risk of cancer during a mean follow-up of four years.
I don't think you are going to find cancer 4 years post artheroplasty.  I think we have done enough short term studies on this now.  We have to start looking at patents 10 years post artheroplastsy.

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