Monday, August 27, 2012

Update on Connie's condition with respect to the cancer reoccurance

Hi fellow bloggers,  I continue to thank you for your interest and concern.  (For those of you who are new to my condition, you can look at the last 5 posts at the bottom of the list on the home page called: about me/my story:  http://www.mydepuyhiprecall.com/p/about-me-my-story.html)

I have selected my cancer experts and the approach to the treatment for this renal cell recurrence based on the very very high likelihood that this hip revision precipitated the oxidative stress process which weakened my immune system and enabled the cancer to reoccur after being cancer free for almost 6 years.  This process is called free radical chemistry. It is well documented in the orthopedic literature when reviewing the process of the degradation of the Chromium and Cobalt.  

The treatment I have chosen is that which is focused on the cancer reoccurring through the process of free radical chemistry. 

In that line, we have chosen an immune therapy approach called interleukin 2 which is the only chance, albeit small, for a cure to my cancer.  I have entered into a NON DRUG trial at one of the top 3 cancer institutes and am being seen by one of the top guys in the field.

While I am enrolled in this study which focuses on a small sub set of renal cell patients (10%) who get these small slow growing tumors, i am starting certain high dose Vitamin therapy which deals with this free radical chemistry until my oncologists (I have 3) feel I am ready for the IL2.

I am diligently researching the key players in the field so that eventually, I can go to Depuy with this information.  

Most physicians have to be presented with the steps involved in redox/free radical chemistry, renal cell,  hip revision surgery with  the links between them all.   This is not something that is readily apparent to them.  Since my treatment approach is based on this, it is important for the members of the team to see the links.

I will be going for repeat scans every 3 months (next one due in October) in order to decide when to start the interleukin 2.

If you have renal cell carcinoma or melanoma, I would think twice about a hip revision if your cancer is in remission.  I would suppose you have to weigh the risks of an implant vs the terminal cancer.

(Note:  make sure you are not reading this to say the hip revision caused the initial cancer.  No.  in my case, the revision precipitated the recurrence of it and put me on a short life path.  Very few renal cell patients recover from this once the metastatic phase is underway which it is in my case...but given the nature of the recurrence, I am hopeful to find something beyond the "normal and customary approaches" to this disease.  Also note that I am not saying there is no link long term between cancer and this MoM hip revision.  Not enough data to draw any conclusions but as you know, I have frequently published on the POTENTIAL cancer link on many occasions on this blog.)

Other links of interest on the blog:

Advances in carcinogenic metal toxicity and potential molecular markers. (1 of x in a series)

Advances in metal-induced oxidative stress and human disease. (2 of x in a series)

Oxidative Stress process associated with Metal on metal hips (series 3 of x)

Oxidative Stress process associated with Metal on metal hips (series 4 of x)

A great pictorial to illustrate the metal on metal oxidation process (5 of 5 in a series)

In biology...... (free radicals, Oxidative stress and reactive oxygen species are covered.)


Free radicals play an important role in a number of biological processes. Some of these are necessary for life, such as the intracellular killing of bacteria by phagocytic cells such as granulocytes and macrophages. Researchers have also implicated free radicals in certain cell signalling processes.[6] This is dubbed redox signaling.


The two most important oxygen-centered free radicals are superoxide and hydroxyl radical. They derive from molecular oxygen under reducing conditions. However, because of their reactivity, these same free radicals can participate in unwanted side reactions resulting in cell damage. Excessive amounts of these free radicals can lead to cell injury and death, which may contribute to many diseases such as cancer, stroke, myocardial infarction, diabetes and major disorders.[7] Many forms of cancer are thought to be the result of reactions between free radicals and DNA, potentially resulting in mutations that can adversely affect the cell cycle and potentially lead to malignancy.[8] Some of the symptoms of aging such as atherosclerosis are also attributed to free-radical induced oxidation of many of the chemicals making up the body.[citation needed]

Because free radicals are necessary for life, the body has a number of mechanisms to minimize free-radical-induced damage and to repair damage that occurs, such as the enzymes superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. In addition, antioxidants play a key role in these defense mechanisms. These are often the three vitamins, vitamin A, vitamin C and vitamin E and polyphenol antioxidants. Further, there is good evidence bilirubin and uric acid can act as antioxidants to help neutralize certain free radicals. 

Reactive oxygen species


Reactive oxygen species or ROSs are species such as superoxide, hydrogen peroxide, and hydroxyl radical and are associated with cell damage. ROSs form as a natural by-product of the normal metabolism of oxygen and have important roles in cell signaling.

     

Oxidative stress is an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.


 As you know, I am not a scientist so sometimes, I may not state things as clearly and articulately as a scientist would.

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