Thursday, August 9, 2012

Oxidative Stress drives tumor progression and metastasis

So, how does this topic relate to the hip?  Hip revisions cause oxidative stress.  In patients with a very healthy immune system (which is likely many patients receiving hip revisions), the immune system is able to deal with the oxidative stress such there is no cancer repercussion.  If however, you are a patient who has cancer or who is in remission and you have a hip revision, it is  probable that the inflammation may cause oxidative stress and the dormant cancer or the cancer in remission could reoccur.

This article is a about how you might deal with this oxidative stress if created.  In this case by using antioxidants.


BMC Med. 2011 May 23;9:62.

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?



Source
The Jefferson Stem Cell Biology and Regenerative Medicine Center, Philadelphia, PA, USA.
Abstract
The functional role of oxidative stress in cancer pathogenesis has long been a hotly debated topic. A study published this month in BMC Cancer by Goh et al., directly addresses this issue by using a molecular genetic approach, via an established mouse animal model of human breast cancer. More specifically, alleviation of mitochondrial oxidative stress, via transgenic over-expression of catalase (an anti-oxidant enzyme) targeted to mitochondria, was sufficient to lower tumor grade (from high-to-low) and to dramatically reduce metastatic tumor burden by >12-fold. Here, we discuss these new findings and place them in the context of several other recent studies showing that oxidative stress directly contributes to tumor progression and metastasis. These results have important clinical and translational significance, as most current chemo-therapeutic agents and radiation therapy increase oxidative stress, and, therefore, could help drive tumor recurrence and metastasis. Similarly, chemo- and radiation-therapy both increase the risk for developing a secondary malignancy, such as leukemia and/or lymphoma. To effectively reduce mitochondrial oxidative stress, medical oncologists should now re-consider the use of powerful anti-oxidants as a key component of patient therapy and cancer prevention. Please see related research article: http://www.biomedcentral.com/1471-2407/11/191.
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[additional comments from connie....yes radiation and chemo might cause the cancer to reoccur due to the oxidative stress.  Oxidative stress is a well documented process which occurs with hip revisions as well.  If you type in oxidative stress into the blog search bar, you can examine all of the evidence for this occurrence.  You can start with this post: http://www.mydepuyhiprecall.com/2012/05/great-pictorial-to-illustrate-metal-on.html]

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