Chemical Speciation of Nanoparticles Surrounding Metal-on-Metal Hips
Long-Term Health Risks Associated with Genotoxic Nanoparticles Released by Failing Metal-on-Metal Hip Implants
A recently published study on failing metal-to-metal hip implant devices reveals that the genotoxic nanoparticles released could cause severe damage to cell DNA.
The study carried out by a team of researchers from Ohio State University and Imperial College, London and published in the online journal of Chemical Communications identified the genotoxic nanoparticles to be not only responsible for inflammation commonly found in hip implant patients but also as a potential source of long-term health risks.
The research team employed high resolution electron and x-ray microscopy to study tissue samples from patients of failing metal-to-metal hip implants for identifying the causes of chronic inflammation suffered by them. They discovered that the inflammation was a result of oxidation of residual chromium shed when the metal implants rub against each other and the release of Cobalt 2+ ions as a result of nanoparticle corrosion in the tissue. Previous studies have established the genotoxicity of Cobalt 2+ ions.
[I have been publishing extensively about the issues surrounding oxidative stress for months now including but not limited to the implications of my own unexpected return of my renal cell carcinoma and these metal on metal hips. You can see these publications here: