Wednesday, June 20, 2012

Progress with 2nd opinions on hip revision and cancer recurrence

I have finished with my consults for the renal cell carcinoma diagnosis and have discussed the connection between the renal cell carcenoma and the hip revision extensively with leading experts in thier respective fields.  I have seen 4 physicians about this link between the hip and the recurrence of cancer:
  • 1 had no idea
  • 1 said the argument could be made between the oxidative stress associated with the hip revision and the recurrence of my renal cell.
  • 1 said yes, there  certainly could be this connection
  • 1 said, very plausible but we can't prove it (not that I was trying to prove it.)  My goal in this exercise was to choose the appropriate treatment for the renal cell after understanding how this recuured when I was released as "cured" from  the initial renal cell nephrectomy 5 years ago.
Given that the oxidative stress issue is an immune/molecular approach to cancer, I will be choosing a treatment for my renal cell that is immune based rather than using the standard of care (angiogenics.)

It was interesting that I found 66 articles in Pub med connecting oxidative stress to renal cell  and it seems to be well accepted that hip surgeries (especially revisions) are associated with creating oxidative stress.  There has been however one study published in the last year questioning whether there is oxidative stress with hip revisions which was conducted  by McGill University researchers.

I have to take a shot and my one shot is going to be with immune therapy based on what I have learned.  I believe there is a very very strong possibility that the revision caused the cancer to recur earlier than it would have otherwise.  Likely, it may have surfaced at some point but we don;t know.

I have written on this topic quite a bit and if you want to look up oxidative stress in the blog  search bar, you will find all of those posts. 

Had I known then what I know now, I might have reconsidered this revision and then suffered the consequence of the high metal levels and the osteolysis.  I often wonder whether both approaches would likely result in cancer.....either the cancer  recurring from the original kidney or having a new one form from the high metal levels over the long run?

Interesting questions.

No comments:

Post a Comment