Thursday, June 14, 2012

3rd Oncology consult relating to the link between the reoccurance of the cancer, the hip revision and treatment options

I saw my last Oncologist from a top treatment facility. As those who read this blog know, I have developed a recurrence of renal cell carcinoma shortly following my hip revision and I wanted to understand whether there was a connection between the recurrence of the cancer and the revision surgery and then determine whether this event this will or will not influence the treatment I select.

Out of the three oncologists I saw, I first one didn't know. The second one didn't know but thought the explanation I provided of oxidative stress was plausible. the third one thought the hip revision could very well have caused the cancer to reoccur earlier than perhaps it may have shown up on its own.

Given these responses, my thought is I am going to seek out treatment from a metabolic and immune based treatment rather than looking at angiogenesis which works to shrink the vesicles enabling the tumor to survive.

I still have my orthopedic consult remaining to discuss this feedback with. In that meeting, I would like to be very sure that I understand the relationship between the oxidative stress that is formed when the Cr6 is oxidized to Cr 3 in the diagram that I have published on several occasions. that process can be found here:
http://www.mydepuyhiprecall.com/2012/05/great-pictorial-to-illustrate-metal-on.html
I would also like to clarify wheather that process is persistently exposed to oxidative stress (on going.) If it turns out to be persistent, I will focus on a potential metabolic approach for treatment. My reason for doing so is that I need to treat the whole picture not merely the symptom (tumor itself.) Given this treatment is not a "standard of care", I will have to pursue clinical trials.


Some additional random points:


(1) Inflammation is a big area of study in medical research because it plays a key role in cancer.

(2) Inflammation is the seen to be virtually the same in different disorders.

(3) By studying inflammation, a better understanding may result in treating things like cancer.

(4) Inflammation is the activation of the immune system in response to infection, irritation, or other things.

(5) Although the pathophysiology is not quite understood reactive oxygen species (ROS) is has often been associated with many conditions such as cancer.

(6) ROS has also been associated with the oxidation of the metals (Cr 6 to Cr 3.)

(7) In fact, in inflammatory diseases the antioxidant defense systemis compromised, as evidenced by increased markers of oxidative stress, and decreased levels of protective antioxidant enzymes.

(8) Oxidative stressplays an important role in carcinogenesis because of induction of DNA damage and its effects on intracellular signal transduction pathways

(9) Oxidative stress plays an important role in the growth and progression of renal cell carcenoma.

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