- metastatic renal cell carcinoma, clear type
- tumor involves the entire ovary
- tumor size: 6.5 x4.7 x4.5 cm
- ovarian surface waws not involved with tumor
- vascular permeation is present
2. Imunohistochemical stains were performed. The results show the following:
- CD10, RCC, PAX-8 show strong postitive stained malignant tumor cells.
- CD10: Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease.
- Pax-8:This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Also functions in very early stages of kidney organogenesis. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized
- RCC/Renal cell carcenoma