Saturday, May 5, 2012

Testing for the metals and related issues are not in but the final path diagnosis is in.

I know my fellow hip patients are interested in the testing of the hip issues relative to my recent diagnosis of the stage 4 renal cell but I don't have them yet.  We have the path report in and here are the highlights from that test:  Final Diagnosis

1.  Ovary:
  • metastatic renal cell carcinoma, clear type
  • tumor involves the entire ovary
  • tumor size:  6.5 x4.7 x4.5 cm
  • ovarian surface waws not involved with tumor
  • vascular permeation is present
[A golf ball is 5cm.  A tennis ball is 7 CM]

2.  Imunohistochemical stains were performed.  The results show the following:
  • CD10, RCC, PAX-8 show strong postitive stained malignant tumor cells.


    • Pax-8:This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Also functions in very early stages of kidney organogenesis.  Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized

    • RCC/Renal cell carcenoma

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