Tuesday, May 22, 2012

Low Molecular weight antioxidants are capable of chelating metal ions like Chromium and cobalt

This was found in an abstract on oxidative stress that I published a few days ago:http://www.mydepuyhiprecall.com/2012/05/advances-in-metal-induced-oxidative.html

"Many low-molecular weight antioxidants (ascorbic acid (vitamin C), alpha-tocopherol (vitamin E), glutathione (GSH), carotenoids, flavonoids, and other antioxidants) are capable of chelating metal ions reducing thus their catalytic activity to form ROS. A novel therapeutic approach to suppress oxidative stress is based on the development of dual function antioxidants comprising not only chelating, but also scavenging components. Parodoxically, two major antioxidant enzymes, superoxide dismutase (SOD) and catalase contain as an integral part of their active sites metal ions to battle against toxic effects of metal-induced free radicals."

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Definition:

Chelation therapy (noun) is the administration of chelating agents to remove heavy metals from the body. Chelation therapy has a long history of use in clinical toxicology. Poison centers around the world are using this form of metal detoxification

Chelation therapy is the use of chelating agents to detoxify poisonous metal agents  such as chromium and cobalt by converting them to a chemically inert form that can be excreted without further interaction with the body, and was approved by the U.S. Food and Drug Administration in 1991

Chelation is the formation or presence of two or more separate coordinate bonds between a polydentate (multiple bonded) ligand and a single central atom.[

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I was in to see my Internist last week and she and I spoke about using some alternative therapies to deal with the metal levels possibly starting pre chemo.... I was curious to see her recommendations and then compared them to the recent abstract reference to other antioxidants.  I wondered what dose levels they would be looking at?

Anyone ever try this or hear of it?  I'm sure that they are megadoses of vitamins.  I found a reference to  a physician who was giving IV megadoses of Vitamin C for this purpose  but it was not well received by the medical community.

Interesting how many options are available albeit, all not well regarded by the medical community.  If anyone has been given high does vitamins therapy for this, I would surely be interested in your story.

1 comment:

  1. Symptoms of neuropathy, extreme fatigue led me to ask doctor for cobalt test. Number reported was 57 mcg/ L. Normal is > 1 mcg/L. Above 7 is toxic. I received a Biomet metal on metal hip implant in 2003. Suspect slow accumulation of cobalt ions. Proximate bone and soft tissue looks good in MRI and X-ray. My orthopedic surgeon consulted with toxicologist ( local ) who said chelation is nearly useless. Could this be true. Iam suffering and feel poisoned.
    Reply to mt at jhkunstler@mac.com

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