Friday, February 10, 2012

Background on Type IV Immune response (part 6 of x)

Info excerpted from MedScape

This is a continuation from 4 prior posts:

Seeking information.......Granulomas, histiocytosis, type IV immune response.... (part 1 of x in this series)

So what is the cause of these pseudotumors after the second revision? (part 2 of x in this series)

Granulomas, necrotic pseudotumors post revision.....what is the story on this? (part 3 of x)

Background on Type IV Immune response (part 4 of x)

Background on Type IV Immune response (part 5 of x)

I am examining this topic of type IV immune response as researchers in the prior posts suggested that the appearance of these "tumors" post surgery might be related to this type of response. I have no idea what they are related to so I thought I would investigate this topic since I am faced with this question in my own situation now


Histologic Findings
The cellular events that result in delayed hypersensitivity reactions primarily involve T cells and macrophages. First, local immune and inflammatory responses at the site of foreign antigen up-regulate endothelial cell adhesion molecule expression, promoting the accumulation of leukocytes at the tissue site. The antigen is engulfed by macrophages and monocytes and is processed and presented to a T cell that has a specific receptor for that processed antigen. Macrophages secrete IL-1, IL-2, IL-6, and other lymphokines. Cytotoxic T cells can also be activated. The recruited macrophages can form giant cells. The characteristic histologic appearance of the macrophage–T-cell infiltrate is a granuloma. This type of infiltrate in the tissue is called granulomatous inflammation


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Next post will look at alternative theories to this  as a cause of the tumors.

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