Tuesday, January 3, 2012

More follow up to the 5 part series on FISH tests used to detect DNA abonormalities as a result of the Chromium and cobalt

I had published a 5 part series beginning on October 21st and concluding on the 25th of October the purpose of which was to show testing that has occurred to determine whether the chromium and cobalt might have altered the underlying genetics of the chromosomes which of course could result in cancer. The first of this series of 5 posts can be found here: http://www.mydepuyhiprecall.com/2011/10/what-are-cytognic-labs-and-why-might.html

 I have found another paper  where this testing was used quite recently.  FISH is an acronym for fluorescence in situ hybridization. 

APMIS. 2010 Nov;118(11):815-23. doi: 10.1111/j.1600-0463.2010.02671.x. Epub 2010 Sep 2.

Improved detection methods for infected hip joint prostheses.


Department of Orthopedic Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark.


Awareness of the role of bacterial biofilm in the pathogenesis of low-grade or chronic infections diagnosed in hip arthroplasty has been on the rise in recent years. The importance of bacterial biofilm for the development of prosthesis failure is probably underestimated, and terms like aseptic loosening, sterile pus and aseptic necrosis are up for revision. The diagnosis of biofilm has been, and still is, difficult, but new molecular biological techniques, alone or in combination with older established ones, have further helped us to uncover lesions, where biofilm is part of the pathology. This article based on a literature search and own observations is primarily focused on newer methods that help us identify the pathology behind infection-based prosthesis failure. We suggest that the fluorescence in situ hybridization technique on carefully selected biopsy material is used in the future to identify live as well as dead bacteria within their environment. The method is quick and sensitive and provides a reliable result with optimal detection rate.

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