Wednesday, December 28, 2011

More DNA studies with nanoparticles such as Chromium and Cobalt and the possiblity of limiting the systemic damage from such particles (Part Two)

This is a continuation of the last post yesterday on the same subject which was published in 2009.  Recall that the subject matter in the last post:

The increasing use of nanoparticles in medicine has raised concerns over their ability to gain access to privileged sites in the body. Here, we show that cobalt–chromium nanoparticles (29.5 plusminus 6.3 nm in diameter) can damage human fibroblast cells across an intact cellular barrier without having to cross the barrier.
This article furthers the study to make the point If the importance of barrier thickness in signalling is a general feature for all types of barriers, our results may offer a principle with which to limit the adverse effects of nanoparticle exposure and offer new therapeutic approaches.
In this case you might make the link from article one to article two (by the same authors) that  wear debris from Chromium and cobalt nanoparticles  can damage DNA by crossing cell barriers and the barrier thickness plays a role, the results from article two may offer a way to limit the adverse effects of this nanoparticle exposure and offer new therapeutic approaches alternatives to Cr and Co?  that is how I read this research.....


Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness

Nature Nanotechnology





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