Friday, October 21, 2011

What are Cytogenic labs and why might the Depuy hip patients have interest in these labs?

Well, I continue to pursue the identification of tests that will provide me with some feedback on the long term biologic effect of the is ware debris on my body.  There is a test that might be available to determine whether  there are measurable chromosome defects as a result of these hips.  Why care?  cancer potential. That's why.  Particulate wear debris accumulates in the tissue adjacent to the prosthesis and disseminates in the body to the liver, spleen, bone marrow and lymph nodes, with the highest levels being detected in the local bone marrow and lymph nodes.

A number of studies have shown a significantly higher rate of chromosomal aberration in local bone-marrow cells adjacent to the prosthesis at revision surgery compared with bone marrow from the iliac crest from the same patient or from a primary hip replacement.

So, my investigation will now begin into the chromosome painting method of fluorescent in situ hybridisation (FISH for short.)  This  is a well recognised and sensitive method for identifying genetic damage.

Just  a quick check of these labs show that the Mayo Clinic has one.  I will most definately check into this now as my surgery is in a few weeks and I would like to be able to get the samples required to run this test.

So, my orthopedic surgeon is very willing to support my testing and he and I have the same question about what I will do with the results.  My answer is to monitor the chromosome damage if there is any from a base line of 5 years.    Resulting damage does not seem to show up for 10 years or longer.

Will write a few more posts on this and then start my phone calling to see if one of these labs will run the baselines.

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