(1) Over the past year, we have reviewed the materials which I think are indicative of the need for additional research in the association of Metal on metal to cancer.
(2) The primary areas of review in this subject matter can be found by going to the home page of the blog and clicking on "Medical Studies" in the top left hand corner. click on that and then scroll down to the systemic effects of metal debris starting with 7c of 7. If you start with 7c and move through 7n (12 posts), you will get a good sense of the issues surrounding cancer and Metal on metal hips.
Systemic effects of metal debris (7c of 7)Systemic effects of metal debris (7c of 7)
(3) I found no study that says Metal on metal hips cause cancer.
(4) I have found that there are two areas of discussion associated with the systemic effects:
- gentotoxic effects (see below)
- Immune mediated (effects)
- changes in the lymphocyte counts
(4) Genotoxicity: I found a number of studies that strongly suggest that metal on metal implants have an effect on chromosome abnormality specifically by creating an abnormal number of chromosomes (aneuploidy) and a rearrangement in parts of the chromosomes (Translocations), both of which could be cancer causing over time,
- Aneuploidy is an abnormal number of chromosomes, and is a type of chromosome abnormality. Some cancer cells have abnormal numbers of chromosomes. Aneuploidy occurs during cell division when the chromosomes do not separate properly between the two cells...The question is what is the relationship between the metal on metal hip and long term systemic effects with things like cancer?
- In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer.
Will come back with the references on the immune system and the oxidation issues above tomorrow.