Wednesday, October 5, 2011

Oxidative stress induced cancers: Is the trivalent chromium really oxidized hexavalent chromium? (3 of x)

    Note: It has been publicized that the Depuy hip contains the less toxic trivalent chromium (aka Chromium 3.) There are quite a number of studies which I have uncovered that suggest the trivalent chromium may be an oxidized hexavalent chromium (aka, chromium 6) which is known to have greater carcinogenic properties than the chromium 3. I have also learned that much of the underlying molecular damage my be due to its intracellular reduction to the even more highly reactive and short lived Chromium 3 and Chromium 5. I hope that someone at some point can clarify the chromium 3 vs 6 issues
Rev Environ Health. 2008 Jan-Mar;23(1):39-57.

Hexavalent chromium-induced DNA damage and repair mechanisms.

Source

Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, Maine 04104-9300, USA.

Abstract

Hexavalent chromium is a commonly used industrial metal that has been shown to induce lung cancer in workers having long term exposure. In the particulate form, Cr(VI) dissolves slowly in vivo, leading to an extended exposure of lung cells. Hexavalent chromium is taken into the cell and rapidly reduced to Cr(V), Cr(IV), Cr(III), and reactive oxygen species. Cells treated with Cr(VI) are subject to several types of DNA damage resulting from this reduction, including base modification, single-strand breaks, double-strand breaks, Cr-DNA adducts, DNA-Cr-DNA adducts, and protein-Cr-DNA adducts. These types of damage, if left unrepaired or are misrepaired, can lead to growth arrest, cytotoxicity, and apoptosis, as well as mutations leading to neoplastic transformation and ultimately tumorigenesis. Here we review the current literature on Cr-induced DNA damage and its repair.

[connie needs to reivew this bibliography.]

4 comments:

  1. Hi Connie, I applaud the amount of work you have put into this blog. I find the information invaluable as I to am a bilateral and have gone through revision on both sides. Unfortuantely, both revisions have been unsuccessful. I have low white blood cell count, specifically overall and lymphocytes. Additionally my platelet count is low. I had my original hips replaced with Cr/Co cups, unknowingly. My question is, have you come across any information about the immune response other than orthopedic metal immune hypersensitivity? Again, your work is incredible to me and I'm sure others. Thanks from the bottom of my heart and God bless

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  2. Hi,

    thanks for you kind comments. Sorry to hear of your issues with teh unsuccessful surgeries.

    The only work I have on the immune response is on the blog. You can search it by just typing in Immune, immune system, immune responce.

    The post yesterday is on this subject and it is rather general. did you have something specific you were looking for?

    Connie

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  3. Hi, sorry for the long delay, I'm having a rough time and have not checked your blog lately. I guess I'm not sure what to look for anymore. I was wondering if you've had any insight into others post revision status. It's hard to find out if other revision patients are having good success after revision or not. I've been to 4 Orthopaedic surgeons and they all say "we don't know what to do". The other statement I really like is "it's only been a year". I'm currently having fluid aspirated out of my hips for evaluation. Thanks again for all you do. I'll continue to read your article and if I find out anything valuable, I'll post.

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  4. Hi,

    Most of the individuals who have written in have not had such great luck but I would not deduce that problems with revisions are the mainstay. People who have no problems generally don't comment.

    I know you are not alone with surgeons being confounded about what to do especially for those who are not experiencing pain.

    So sorry you are having continued problems.

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