Monday, October 17, 2011
Effects of Cobalt Nanoparticles on Human T Cells In Vitro.
[ Connie's preamble: I have spent a number of months looking at the potential genotoxic effects of Chromium on cells in patients with hip implants. I just noted this article which talks about the potential gentoxic/cytotoxic effects that Cobalt might have on the patients T cells. This article was released pre publication in the journal.
In genetics, genotoxicity describes a deleterious action on a cell's genetic material affecting its integrity
T cells or T lymphocytes belong to a group of white blood cells known as lymphocytes, and play a central role in cell-mediated immunity. Lymphocytes identify invaders in the body and destroy them. In this case, we would be targeting Cobalt as an invader in the body which the system would want to wipe out. If the T lymphocytes are not working properly and are inhibited, problems could arise of various sorts. The function of T cells and B cells is to recognize specific “non-self” antigens, during a process known as antigen presentation. Once they have identified an invader, the cells generate specific responses that are tailored to maximally eliminate specific pathogens or pathogen infected cells. B cells respond to pathogens by producing large quantities of antibodies which then neutralize foreign objects like bacteria and viruses.
These tests were conduced in vitro. that is, they are lab experiments NOT conducted on humans or organisms.]
Biol Trace Elem Res. 2011 Oct 4. [Epub ahead of print]
Posted by Connie at 2:49 PM