Tuesday, September 13, 2011
Reviewing the historical Journal literature for publications discussing Cancer risk associated with joint/hip implants (8 of x)
(this series is looking at articles that began suspecting the relationship between cancer risk and metal on metal hips since 1995.)
Couple of definitions might be in order before you read this abstract:
In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer.
Aneuploidy is an abnormal number of chromosomes, and is a type of chromosome abnormality. An extra or missing chromosome is a common cause of genetic disorders (birth defects). Some cancer cells also have abnormal numbers of chromosomes.
Senescence or biological aging is the change in the biology of an organism as it ages after its maturity. Such changes range from those affecting its cells and their function to that of the whole organism. There are a number of theories as to why senescence occurs, including ones that claim it is programmed by gene expression changes and that it is the accumulative damage of biological proces
In mitosis, one cell divides to produce two genetically identical cells
In genetics, genotoxicity describes a deleterious action on a cell's genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumors
Remember, this study is looking at effects from metal on metal in vitro (isolated lab type experiment) vs in vivo whereby the test is done on the organism in its normal intact state.
Mutat Res. 2007 Jun 1;619(1-2):45-58. Epub 2007 Jan 25.
Posted by Connie at 2:34 PM