Saturday, September 10, 2011

Reviewing the historical Journal literature for publications discussing Cancer risk associated with joint/hip implants (5of x)

I think observations have progressed since this article was published however it is clear that the  questions surrounding carcinogens, while surfaced in the literature since mid 1995 at least, there has been no concerted effort to study it even through today.  There may be some reasons for that such as not having adequate data collected on metal on metal hips for at least 10 years or longer.  It is important to know how long these questions and observations have been surfacing.....over a decade.

Clin Orthop Relat Res. 2003 Dec;(417):139-47.

Metal degradation products: a cause for concern in metal-metal bearings?


Department of Orthopedic Surgery, Rush Medical College, 1653 W. Congress Parkway, Chicago, IL 60612, USA.


In the majority of patients, orthopaedic implants are biocompatible. However, there is an increasing recognition that, in the long-term, permanent orthopaedic implants may be associated with adverse local and remote tissue responses in some individuals. These adverse effects are mediated by the degradation products of implant materials. The recent reintroduction of metal-on-metal bearings for total hip arthroplasty has heightened concerns about the biologic response to metal degradation products in light of the fact that the serum and urine metal concentrations in patients with these implants typically are higher than those seen in patients with conventional metal-on-polyethylene bearings. From previous studies of long-term metal-on-metal McKee-Farrar implants, it seems that these elevated levels may persist for the duration of the implant's lifetime. This is of particular concern in the younger and more active patient in whom life expectancy after implantation may exceed 30 years. The association of metal release from orthopaedic implants with any metabolic, bacteriologic, immunologic, or carcinogenic toxicity currently remains conjectural because cause and effect have not been established in human subjects. However, continued surveillance of patient populations with metal implants, particularly those with metal-metal bearings, is warranted.

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