Monday, September 5, 2011

Reviewing the historical Journal literature for publications discussing Cancer risk associated with joint/hip implants (1of x)

I was interested in discovering  the initial cancer discussions re hip implants so I decided to look at the medical journal articles published to determine the  frequency of this issue being raised historically.  I found 11 such articles starting pre 1995 which I have not published in the, with the exception of 1 document that covers 4 studies pre 1995.  This will be a sequence of 8 documents which I will examine each day to show both sides of the issue.  I will reprint the post which refers to the first 4 studies conducted prior to 1995 and will review them at the conclusion of this series.

It is clear that there is a current debate on this but you would think that after 15 years, standard testing would have commenced on patients routinely.

This post appeared on July 6th on the blog:

Hematological malignancies are the types of cancer that affect blood, bone marrow, and lymph nodes. As the three are intimately connected through the immune system, a disease affecting one of the three will often affect the others as well: although lymphoma is technically a disease of the lymph nodes, it often spreads to the bone marrow, affecting the blood

Development of hematopoietic cancers after implantation of total joint replacement.

Clin Orthop Relat Res. 1996 Aug;(329 Suppl):S290-6.

Gillespie WJ, Henry DA, O'Connell DL, Kendrick S, Juszczak E, McInneny K, Derby L.


Department of Orthopaedic Surgery, University of Edinburgh, Scotland.


The evidence from the 4 epidemiologic studies published before mid 1995, which have investigated the incidence of cancers in patients who have undergone joint implants, is conflicting. The results of the 2 earlier studies suggested a sustained increase in the risk of lymphoma and leukemia after total hip arthroplasty. The results of the 2 more recent studies have not confirmed this, although in 1 study an increased risk was observed in the first year after implantation. The heterogeneity may be statistical in origin, but could also have a biologic explanation in the greater proportion of metal on metal prostheses used before 1973. All 4 studies used national data as the comparison. Here, are presented the results of 2 matched cohort studies and a case control study set in North America and Scotland, and an overview of the 4 previous studies. Neither the results of the matched studies of patients operated on after 1973 nor the results of the latter 2 published studies suggest an increased risk of lymphoma or leukemia. If metal on metal articulations are reintroduced, careful surveillance is essential.

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