Sunday, September 4, 2011

Polyethylene and metal wear particles: characteristics and biological effects.

This looks like a very interesting paper which I will explore in more detail this week.  It is published by the same authors as the prior post.
Semin Immunopathol. 2011 May;33(3):257-71. Epub 2011 Jan 26.


Department of Mechanical Engineering, Departments of Surgery & Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.


This paper first presents a brief overview about the mechanism of wear particle formation as well as wear particle characteristics in metal-on-polyethylene and metal-on-metal artificial hip joints. The biological effects of such particles are then described, focusing on the inflammatory response induced by each type of particles as well as on how metal wear products may be the source of a T lymphocyte-mediated specific immune response, early adverse tissue responses, and genotoxicity. Finally, some of the current in vivo models used for the analysis of tissue response to various wear particles are presented.

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