- Wolf et al 1989
- Landon et al 2004
- Bacon et al 1983
- Martnett et al 1999
- Hartwig et al 2003
- Witkiewicz-Kucharczyk and Bal 2006
Final post on metal-induced intracellular effects
Landon investigated changes in metal ion levels and chromosome aberrations in patients within 3 years of receiving the Metal on metal hip artheroplasties. The authors noted an increase in chromosome translocations* and aneuplody** in periperheral blood lymphocytes at 6, 12 and 24 mos post surgery. They also noted the changes were progressive. The authors didn't find any statistically significant correlations between chromosomal translocation indices and Co or Cr concentrations in whole blood.
*chromosome translocations-In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer.
**aneuploidy-Aneuploidy is an abnormal number of chromosomes, and is a type of chromosome abnormality. An extra or missing chromosome is a common cause of genetic disorders (birth defects). Some cancer cells also have abnormal numbers of chromosomes.