Genotoxic issues surrounding systemic effects of metal debris (continued from prior posts)
The committee on mutagenicity has reported that internal exposure to orthopedic metals is associated with increased genotoxicity.
This is a series of commentary from the committee on mutangenicity evidence based on the the key journal articles examined by that committee. I think you will find the results really interesting if you are concerned about the systemic effects of the metal.
I said this would be the last in this series however, there seem to be 6 items provided in confidence and I am going to try to locate the source data (more time so I myself would like to take time to review each one daily.
6th and final group of comments from the committee (In confidence data sumbitted by the BIRC)...[6 individual comments provided.. 6-11]
6 of 6
Members of the committee briefly discussed potential mechanisms by which metal ions could induce the effects on DNA repair and fidenlity and inductionof oxidatvie DNA damage. It was agreed that the biomonitoring and war debris studies provided has not provided convincing evidencee for an interaction between the metals or for metal specifica mutagenic effects. However the possiblity of interactions between metal ions with regard to mutagenic effects could not be discounted.
Cobalt and antimony: genotoxicity and carcinogenicity.
SourceLaboratorium voor Cellulaire Genetica, Vrije Universiteit Brussel, Pleinlaan 2, Brussel 1050, Belgium.
- Mutat Res. 2004 Apr 14;548(1-2):127-8.