Sunday, July 24, 2011

Review of the Cell biology surrounding metal on metal hips (6 of x in a series)

In the last few posts, we examined the effects of metal particles on bone cells.  In the last post, we talked about Ostoblasts (cells that make the bone) and how the metal particles adversely affect the functionality of those cells.
 
The material for these articles are sourced through the the following journal article:
 
Acta Orthop. 2008 Dec;79(6):734-47.
Metal-on-metal hip resurfacing arthroplasty: a review of periprosthetic biological reactions.
Mabilleau G, Kwon YM, Pandit H, Murray DW, Sabokbar A.


Osteoclasts (not to be confused with Osteopblasts): are a type of bone cell that removes bone tissue by removing its mineralized matrix and breaking up the organic bone (organic dry weight is 90% collagen). This process is known as bone resorption

(1) It has been shown that Co (cobalt) ions induced the death of osteoclast precursors after several weeks of co-culture with bone marrow cells.

(2) Studies have been conducted on rabbits bone marrow with the results showing that cell death did not occur but once the metal  was introduced after 4 days of Co ions, a decrease in the size of the mature osteoclasts.

The next posts will address the metal ions in cells.  We will look at the metal transport in cells and the metal-induced intracellular effects to show how the  permanent change in the genetic material (DNA) occurs which represents the first step in the carcinogenesis.

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