Mabilleau G, Kwon YM, Pandit H, Murray DW, Sabokbar A.
Osteoblasts-cells that are responsible for bone formation
1. Metal ions can influence the biology of osteoblasts
2. Exposure to metal ions can result in a dysregulation of osteoblasts and osteoblast-like cells.
3. Although the metal ion concentrations within the bone in vivo has not been established, exposure of ostoblasts to /Cobalt particles at concentrations of of 100ug/L or higher, leads to the development of certain changes in the cell (vacuole creation.)
4. Cr and Co ions are toxic for osteoblasts leading to markedly reduced activity with certain molecules that prevent organic molecules from passing through the cell membrane.
5. A decrease in protein, DNA, and RNA synthesis has been shown with Co and Cr ions.
6. Certain proteins are important for the calcification of bone matrix.
7. These protiens are synthesized by ostoblasts and released into the extracellular matrix.
8. Cr and Co inhibit the release of ostocalcin into the bone matrix contributing to the delay in mineralization of the bone tissue following exposure to the metal.