Sunday, July 17, 2011
Review of the Cell biology surrounding metal on metal hips (1 of x in a series)
This review seems to be the most recent recap describing the biology of what happens in a cell when it comes into contact with the Chromium and Cobalt. This topic is of interest because it provides the clues as to what the long term systemic bilogical consequences of the exposures to these particles might be.
Given the techncal nature of this subject, I will break this down into a series of commentaries on the content. I don't know how many posts will be required to cover this topic so will leave the series open ended (x.)
The following abstract will serve as the base document for comments.
I have gained some understanding of the link between the change in cell biology that is caused by these metal on metal hips and the possible assocation over time with cancer from reading this document. Understand, there have been no direct links showing cause and effect (metal from the hip causes cancer) but my sense from reading all of these documents is that it is not because there is no link but because there has not been enough data collected from the patients who have these hips in place over time to demonstrate unequivocally that there is a link. The early studies in this arena whereby data has been collected over a 10 year period , have certainly demonstrated that over that time frame, the changes in the cell biology (DNA) which occur are those which are seen in Lymphoma (cancer of the immune system) and Leukemia (Leukemia is cancer of the blood cells. It starts in the bone marrow, the soft tissue inside most bones.) That doesn't mean one causes the other necessarily. It means that there are similarities in the processes.
In prior articles, I have demonstrated that there is certainly enough seminal research in this field to strongly support the need for a concentrated effort in this area of research. I believe that the company's manufacturing the metal on metal hips should, in part, underwrite these studies as a part of the hip litigation settlement.
As usual, I want to remind the readers that I am not a medical researcher nor do I have any training in this area of study. I can only provide my own commentary into the questions. I have no answers.
Acta Orthop. 2008 Dec;79(6):734-47.
Posted by Connie at 4:21 AM