Wednesday, July 6, 2011
Quantification of t(14;18) in the lymphocytes of healthy adult humans as a possible biomarker for environmental exposures to carcinogens.
[comments by connie: So, here is a test that can detect possible cancers from blood lymphocytes-T (14;18) which was discussed by the committee on mutagencity/genotoxicty. This will go on my to do list to discuss with my surgeon. The question is, if there is concern regarding the possible association of metal induced cancers with total hip replacement (THA) that suggest that there is an increased risk of lymphoma and leukemia in patients with THA (reference was the jenkins article I published a few days ago) , how do you test for that? While none of us likely understand the terminology in the above abstract, this is a test that I would like to have a look at. I have been looking for some more recent methodologies but have found none....yet.
The other thing I find interesting about this is, my prior understanding was that "environmental" cancer data/testing is not readily portable to understanding hip stuff. Well, I think we need to question that. If there is a way to measure these chromosome translocations that are purportedly associated with metal induced cancers, then why would we not want to test this?
(In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer.)]
Posted by Connie at 2:39 PM