Saturday, July 30, 2011

Chromium 3 results in permanent modification to DNA in MoM hips. (1 of 6.) What does this mean?

I wanted to explore 5 references from the prior series re the effect the Chromium 3  (contained in the Depuy hip and is presumably the non toxic form of Chromium) has on making permanent modification of the genetic material of the DNA hence represents the first step in carcinogenesis.  I don't believe I have reviewed these references before. 

This does not mean the Chromium 3 causes cancer!   It doesn't mean that it doesn't cause cancer either.  It is my understanding that the meaning of all of this is unclear in terms of its long term effects.

I would like to  understand what it means when they say that "direct binding of Cr3 to DNA is well documented"  and why this matters to us as patients.
  • Wolf et al 1989
  • Landon et al 2004
  • Bacon et al 1983
  • Martnett 1999
  • Hartwig et al 2003
I will explore this in a series of 6 posts, this being post one  which is a brief review of  post 8 Review of the Cell biology surrounding metal on metal hips (8 of x in a series)  .

5. Permanent modification of genetic material resulting from this "oxidative damage" [From the MOM hips] represents the first step in mutagenesis*, carcinogenesis** and ageing.

*mutagenesis-process by which the genetic information of an organism is changed.
**carcinogenesis-is literally the creation of cancer.

6. Although no evidence has been found for direct binding of Co2 to DNA, direct binding of Cr3 to DNA is well documented (Wolf et al, 1989)

7. Two main processes exist to correct DNA aberrations and to restore the integrity of the genome.

8. Both of these repair mechanisms are inhibited with Cr3.

9. Landon investigated changes in metal ion levels and chromosome aberrations in patients within 2 years of receiving Metal on Metal hips. The authors noted an increase in translocations* and aneuploidy** in peripheral blood lymphocytes at 6, 12 and 24 months after surgery.

*Translocations-In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A gene fusion may be created when the translocation joins two otherwise separated genes, the occurrence of which is common in cancer.

**aneuploidy- is an abnormal number of chromosomes, and is a type of chromosome abnormality. An extra or missing chromosome is a common cause of genetic disorders (birth defects). Some cancer cells also have abnormal numbers of chromosomes.

I will look at each of the 5 journal references in the next 5 posts.


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