Genotoxic issues surrounding systemic effects of metal debris (continued from prior posts)
The committee on mutagenicity has reported that internal exposure to orthopedic metals is associated with increased genotoxicity.
This is a series of commentary from the committee on mutangenicity evidence based on the the key journal articles examined by that committee. I think you will find the results really interesting if you are concerned about the systemic effects of the metal.
Second piece of evidence:
Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty.
SourceUniversity of Bristol, Orthopaedic Surgery, BIRC-Bristol Implant Research Center, Bristol, UK.
- The increase in the number of chromosomes was much greater than that of chromosome abnormality and both were progressive over time.
- Many more patients were studied this time around compared to the Doherty study that I reviewed on Saturday the 18th of June.
- The blood measurements had been adequately taken
- the evaluation of chromosome aberrations had been adequately undertaken and reported
- Further information should be reviewed on the question of the agents that resulted in cell division
- The members concluded that the evidence from these tow studies supported the involvement of released Chromium and cobalt in the observed chromosomal effects associated with MoM hip replacement although, it was not possible to to conclude whether this was due to release of soluble ions or particulate metals.
Gee, I can't wait to see the last 3 studies!