Genotoxic issues surrounding systemic effects of metal debris (continued from prior posts)
The committee on mutagenicity has reported that internal exposure to orthopedic metals is associated with increased genotoxicity.
This is a series of commentary from the committee on mutangenicity evidence based on the the key journal articles examined by that committee. I think you will find the results really interesting if you are concerned about the systemic effects of the metal.
First piece of evidence:
Increased chromosome translocations and aneuploidy in peripheral blood lymphocytes of patients having revision arthroplasty of the hip.
SourceBristol Implant Research Centre and the University Department of Orthopaedic Surgery, England.
- The patient sample was small and it would not be possible to draw any definite conclusions re differences between different types of Metal on Metal devices.
- The procedures used in testing the blood metal levels were done appropriately
- The evaluation of these two gene mutations mentioned above had been adequately reported
- Members wanted to see the full details of the tests.
You can draw your own conclusion from the above. I am eager to see the next 4 papers.