Tuesday, May 10, 2011

Helpful consolidated ion toxicity numbers, 1-2 years post op for MOM large femoral head implants

 I found this summary  to be very interesting.  It  provides the first real consolidated benchmark I have seen from which to judge, “how high is high” with respect to ion levels in MOM atheroplasty,  albeit, the data is limited to 24 months post op.  It would be interesting to see the data over a longer time frame.  One of my consults provided the first 4 rows of this chart.  I added the 5th row as I was curious about the population size these results were based on.
Published studies with MOM implants (surface replacements which have large femoral heads)
Serum Metal Ion Levels (ng/ml or ppb**) 


Months post op
Serum Cr
Serum Co
Number of patients (I looked up the  studies and added this row )
Patients with Conserve Plus surface  replacements at 1 year/Skipor et al 2002
12
1.80 +- .45
1.07 +- .26
Information not contained in the abstract
BHR-Wizleb et al 2006
12
4.2

Looks like about 111 patients in the full study

24
5.2
4.28
BHR-Beck et al 2005
12
4.0 (.62-9.88)
2.37 (1.06-6.71)
Information not contained in the abstract

24
3.53 (1.3-6.14)
1.87 (.88-3.30)
Cormet  2000-Allan et al 2007
12
5.12
4.31
Looks like about 35 patients

24
3.75
2.75
BHR-Moroni et al
24
2.30 +1.72
(.69-7.24)
1.4+.47
(.08-8.96)
Information not contained in the abstract
BHT- Langton et al 2009
12
3.55 (.65-190)
1.65 (1.8-76)
Looks like about  70 patients
ASR-Langton et al 2009
12
3.99 (.58-115)
2.3 (.38-228)
Looks like about 90 patients


**These comparative values should be interpreted with caution as each lab uses their own protocols for analysis.  Results and methods  vary.
  If you want to see the study attribution list, I can add those.  LMK

2 comments:

  1. Dear Connie,
    I am concerned about my levels and have been for over 10 years. I had a biomet m/m in 2000.
    My first Metal Ion test scores scared the s*&^t
    out of me and docs. Then they got higher, and I wonder why I never see mine in any medical papers?
    my cobalt chromium & titanium levels are as follows:
    Cobalt: 3180.86nmo/L normal is below 3.9nmo/L
    Chromium: 1248.03 normal is below 5.8
    to see actual test go to Julie Payne-King in facebook

    ReplyDelete
  2. Hi Julie,

    While these levels are high, the metal levels alone are only one piece of the puzzle. Have you had any MRIs? Have these levels persisted over the 10 years? Are you symptomatic of pain?

    Likely your surgeon as asked all of these questions and has a monitoring plan in place for you. I would certainly want to be monitored with these levels and I assume you have such a plan.

    Regards,

    Connie

    ReplyDelete