Tuesday, March 22, 2011

Is there a casual relationship between metal hypersensitivity and osteolyis with Depuy hip?

Could there be a link between osteolyis and metal hypersensitivity potentially from a parathyroid issue?  Bone resorption (aka osteolyis) is the process by which osteoclasts break down bone[1] and release the minerals, resulting in a transfer of calcium from bone fluid to the blood.  Osteoclasts are also prominent in the tissue destruction.
Calcium-sensing membrane receptors in the parathyroid gland monitor calcium levels in the extracellular fluid.  Low levels of calcium stimulate the release of parathyroid hormone (PTH) from chief cells of the parathyroid gland. In addition to its effects on kidney and intestine, PTH also increases the number and activity of osteoclasts to release calcium from bone, and thus stimulates bone resorption.

High levels of calcium in the blood, on the other hand, leads to decreased PTH release from the parathyroid gland, decreasing the number and activity of osteoclasts, resulting in less bone resorption.

If you are asymptomatic with a depuy hip, on your next vist to your physcian, I would ask to see  your calcium levels and PTH levels since you had the hip implant.  Ask your physcian if the levels are high or low consistantly since the implant?   Low calcium levels might contribute to higher bone resporption.

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