Thursday, February 10, 2011

Total hip replacement and cancer. A cohort study. (Ion toxicity abstracts 1 of 14.)

J Bone Joint Surg Br. 1995 May;77(3):345-50. Mathiesen EB, Ahlbom A, Bermann G, Lindgren JU; Department of Orthopaedic Surgery, Karolinska Institute, Huddinge University Hospital, Sweden.


The incidence of cancer after hip replacement was studied in the 1.6 million inhabitants of Stockholm County, Sweden. A cohort of 10,785 individuals who had had hip replacement between 1974 and 1988 was followed from the date of operation to the first malignant tumor, to death, or to the end of 1989. The follow-up was based on 58,437 person-years at risk as calculated from information obtained by record-linkage with the National Cancer Registry and the National Cause-of-Death Register. The Standardized Morbidity Ratio (SMR) for all cancer sites, disregarding the length of follow-up, was 0.96 (95% CI 0.90 to 1.03). For lymphoma and leukemia the corresponding SMR was 0.89 (0.68 to 1.14). Our results do not support previous suggestions of an increased incidence of leukemia and lymphoma after total hip replacement.

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