Friday, January 7, 2011

Shocking excerpts on the issue of metal toxicity associated with Hip implants from various medical journals that I found of interest:

1)      Selected chromium compounds, particularly hexavalent ones (found in meal implants) are carcinogens and have the kidney as their primary target organ.

2)      The cobalt-chorme-molybdenum alloys are widely used in orthopedic implants.  Complications still occur and sometimes appear to be due to incomplete biocompatibility of the alloy.

3)      Although carcinogenic metals have been known to disrupt a wide range of cellular processes, the precise mechanism by which these exert their carcinogenic effect is not known.

4)      *Epigenetic mechanisms may play a role in metal-induced carcinogenesis.  That is something such as metal may cause a change in enzymes involved in “writing” and “erasing” the reversible marks on DNA.

5)      Today, cancer is the disorder most commonly associated with the change in DNA from outside sources like metal.

6)      Recent developments in the field of carcinogenesis suggest that these mechanisms may play a role in activating or silencing the expression of the gene critical for driving the metal induced carcinogens.

7)      With Chromium, various reactions can affect DNA replication, transcription and translation resulting in altered gene expression.

*epigenetics is the study of inherited changes in phenotype (appearance) or gene expression caused by mechanisms other than changes in the underlying DNA sequence.  These changes may remain through cell divisions for the remainder of the cell's life and may also last for multiple generations. However, there is no change in the underlying DNA sequence of the organism;[1] instead, non-genetic factors cause the organism's genes to behave (or "express themselves") differently.[2]

I find all of this stunning information.  If this is in fact true, I read this to say that the metals used in the hip replacements can irrevocably alter the underlying genes that can result in causing cancer.  That is, the metal can actually change what the gene does.  I am not a doctor nor an expert in any of this but this is what I gleaned from reading the studies. 

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